Looking Back to Look Forward: What to Expect in a Redo Surgery for a Bioprosthesis Replacement

J Clin Med

19 Gennaio Gen 2023 16 days ago
  • Giambuzzi I, Bonalumi G, Bonomi A, Zanobini M.

Redo surgeries are becoming more common because of an increased rate of bioprosthesis implantation. We performed a retrospective study on patients who underwent redo replacement of an aortic and/or mitral bioprosthesis between 2005 and 2018 to evaluate intra-hospital mortality and morbidity. Univariate analysis was performed on the propensity score variables to determine predictors of mortality. A total of 180 patients were enrolled in the study: Group A (replacement of aortic bioprosthesis) with 136 patients (75.56%) and group B (replacement of mitral bioprosthesis ± aortic bioprosthesis) with 44 patients (24.44%). NYHA class ≥ 3 and female sex were significantly more common in group B. Cardiopulmonary-bypass time and aortic cross-clamping time in group A and group B were, respectively, 154.95 ± 74.35 and 190.25 ± 77.44 (p = 0.0005) and 115.99 ± 53.54 and 144.91 ± 52.53 (p = 0.0004). Overall mortality was 8.89%. After propensity score adjustment, Group B was confirmed to have an increased risk of death (OR 3.32 CI 95% 1.02-10.88 p < 0.0001), gastrointestinal complications (OR 7.784 CI 95% 1.005-60.282 p < 0.0002) and pulmonary complications (OR 2.381 CI 95% 1.038-5.46 p < 0.0001). At the univariate analysis, endocarditis, cardiopulmonary-bypass and aortic cross clamping time, NYHA class ≥ 3 and urgency setting were significantly associated to death. Intra-hospital outcomes were acceptable regarding mortality and complications. Patients who need redo surgery on mitral bioprosthesis have an increased risk of post-operative pulmonary and gastrointestinal complications and mortality. Therefore the choice of mitral bioprosthesis at time of first surgery should be carefully evaluated.

Reference: Looking Back to Look Forward: What to Expect in a Redo Surgery for a Bioprosthesis Replacement. Giambuzzi I, Bonalumi G, Ballan G, Messi P, Bonomi A, Maggiore A, Esposito G, Di Mauro M, Alamanni F, Zanobini M. J Clin Med. 2022 Nov 30;11(23):7104.

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