In the last years, a substantial contribution of red blood cells (RBCs) in cardiovascular homeostasis has been evidenced, as these cells are able to regulate cardiovascular function by the export of adenosine triphosphate and nitric oxide as well as to maintain redox balance through a well-developed antioxidant system. Recently a link between high-risk plaque (HRP) features and myocardial ischemia, in the absence of severe lumen stenosis, has been evidenced. Nonobstructive coronary artery disease (nonob CAD) has been associated in fact with a greater 1-year risk of myocardial infarction and all-cause mortality compared with no apparent CAD. This new evidence increases interest in searching new triggers to identify these high-risk patients, in the absence/or on top of traditional hazard markers. In this study, we investigated the existence of any association between RBC morphodynamics and HRP features in individuals with different grades of coronary stenosis detected by coronary computed tomography angiography (CCTA).
Porro B, Conte E, Zaninoni A, Bianchi P, Veglia F, Barbieri S, Fiorelli S, Eligini S, Di Minno A, Mushtaq S, Tremoli E, Cavalca V, Andreini D. Red Blood Cell Morphodynamics: A New Potential Marker in High-Risk Patients. Front Physiol 2021 Jan 13;11:603633. doi: 10.3389/fphys.2020.603633.