Human serum albumin (HSA) is the most abundant circulating protein in the body and presents an extensive range of biological functions. As such, it is prone to undergo post-translational modifications (PTMs). The non-enzymatic early glycation of HSA, one of the several PTMs undergone by HSA, arises from the addition of reducing sugars to amine group residues, thus modifying the structure of HSA. These changes may affect HSA functions impairing its biological activity, finally leading to cell damage. The aim of this study was to quantitate glycated-HSA (GA) levels in the plasma of heart failure (HF) patients and to evaluate the biological effects of GA on HL-1 cardiomyocytes.
Fernandez AM, Regazzoni L, Brioschi M, Gianazza E, Agostoni P, Aldini G, Banfi C. Pro-oxidant and pro-inflammatory effects of glycated albumin on cardiomyocytes. Free Radic Biol Med 2019 Jun 28. pii: S0891-5849(18)32565-6. doi: 10.1016/j.freeradbiomed.2019.06.023.