Serum from COVID-19 patients promotes endothelial cell dysfunction through protease-activated receptor 2.

Inflamm Res

5 Gennaio Gen 2024 one month ago
  • Brambilla M, Camera M.

Endothelial dysfunction plays a central role in the pathophysiology of COVID-19 and is closely linked to the severity and mortality of the disease. The inflammatory response to SARS-CoV-2 infection can alter the capacity of the endothelium to regulate vascular tone, immune responses, and the balance between anti-thrombotic and pro-thrombotic properties. However, the specific endothelial pathways altered during COVID-19 still need to be fully understood.

Reference: Serum from COVID-19 patients promotes endothelial cell dysfunction through protease-activated receptor 2.
Vieceli Dalla Sega F, Fortini F, Licastro D, Monego SD, Degasperi M, Ascierto A, Marracino L, Severi P, D'Accolti M, Soffritti I, Brambilla M, Camera M, Tremoli E, Contoli M, Spadaro S, Campo G, Ferrari R, Caselli E, Rizzo P. Inflamm Res. 2023 Dec 20.

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