Hyperventilation and inadequate cardiac output (CO) increase are the main causes of exercise limitation in pulmonary hypertension (PH). Intrapulmonary blood flow partitioning between ventilated and unventilated lung zones is unknown. Thoracic impedance cardiography and inert gas rebreathing have been both validated in PH patients for non-invasive measurement of CO and pulmonary blood flow (PBF), respectively. This study sought to evaluate CO behaviour in PH patients during exercise and its partitioning between ventilated and unventilated lung areas, in parallel with ventilation partitioning between ventilated and unventilated lung zones.
Reference: Intrapulmonary distribution of blood flow during exercise in pulmonary hypertension assessed by a new combination technique.
Farina S, Pezzuto B, Vignati C, Laveneziana P, Agostoni P. Front Cardiovasc Med. 2023 Sep 8;10:1241379.