Fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) is superior to angiography-guided PCI. The clinical uptake of FFR has been limited, however, by the need to advance a wire in the coronary artery, the additional time required and the need for hyperaemic agents which can cause patient discomfort. FFR derived from routine coronary angiography eliminates these issues. The aim of this study was to assess the diagnostic performance and accuracy of three-dimensional quantitative coronary angiography (3D-QCA)-based vessel FFR (vFFR) compared to pressure wire-based FFR (≤0.80).
Vessel fractional flow reserve (vFFR) for the assessment of stenosis severity: the FAST II study. Masdjedi K, Tanaka N, Van Belle E, Porouchani S, Linke A, Woitek FJ, Bartorelli AL, Ali ZA, den Dekker WK, Wilschut JM, Diletti R, Zijlstra F, Boersma E, Van Mieghem NM, Spitzer E, Daemen J. EuroIntervention. 2021 Oct 14:EIJ-D-21-00471. doi: 10.4244/EIJ-D-21-00471