Arrhythmogenic Cardiomyopathy (AC) is a familial cardiac disease, mainly caused by mutations in desmosomal genes. AC hearts show fibro-fatty myocardial replacement, which favors stress-related life-threatening arrhythmias, predominantly in the young and athletes. AC lacks effective therapies, as its pathogenesis is poorly understood. Recently, we showed that cardiac Mesenchymal Stromal Cells (cMSCs) contribute to adipose tissue in human AC hearts, although the underlying mechanisms are still unclear.
Neuropeptide Y promotes adipogenesis of human cardiac mesenchymal stromal cells in arrhythmogenic cardiomyopathy. Stadiotti I, Di Bona A, Pilato CA, Scalco A, Guarino A, Micheli B, Casella M, Tondo C, Rizzo S, Pilichou K, Thiene G, Frigo AC, Pompilio G, Basso C, Sommariva E, Mongillo M, Zaglia T. Int J Cardiol. 2021 Aug 13:S0167-5273(21)01226-2. doi: 10.1016/j.ijcard.2021.08.015