Human monocyte-derived macrophages: Pathogenetic role in plaque rupture associated to systemic inflammation

Il ruolo dei macrofagi nel destabilizzare la placca aterosclerotica (Int J Cardiol 2020 Oct 6;S0167-5273(20)33901-2)

5 Novembre Nov 2020 22 days ago
  • Cosentino N, Eligini S, Fiorelli S, Fabbiocchi F, Marenzi G, Tremoli E

Macrophages play a key role in coronary plaque destabilization. In-vitro human monocyte-derived macrophages (MDMs) are used to study macrophages infiltrating tissue. Optical coherence tomography (OCT) provides an in-vivo insight of the coronary arteries.

The Authors of this study compared the MDMs morpho-phenotype and culprit plaque features at OCT in acute coronary syndrome (ACS) patients according to the underlying plaque pathobiology.

According to the results, the monocyte-derived macrophages of ACS patients show morpho-phenotypic heterogeneity with prevalence of pro-thrombotic and pro-oxidative properties in case of plaque rupture and systemic inflammation. Such MDMs subpopulation may take part to the cellular pathways leading to fibrous cap rupture with the subsequent thrombus formation.


Reference
1. Fracassi F, Niccoli G, Cosentino N, Eligini S, Fiorelli S, Fabbiocchi F, Vetrugno V, Refaat H, Montone RA, Marenzi G, Tremoli E, Crea F. Human monocyte-derived macrophages: Pathogenetic role in plaque rupture associated to systemic inflammation. Int J Cardiol 2020 Oct 6;S0167-5273(20)33901-2. doi: 10.1016/j.ijcard.2020.09.071. Go to PubMed