Osteopontin (OPN) is involved in ectopic calcification. Its circulating form is upregulated in coronary artery disease (CAD) patients. Circulating OPN levels positively correlate with oxidative stress, one of the major triggers of endothelial dysfunction. Endothelial dysfunction is, in turn, associated with reduced nitric oxide (NO) bioavailability due to the impaired arginine pathway. The aim of this study was to better understand the correlations between OPN, oxidative stress markers, and the arginine pathway metabolites.
Moschetta D, Di Minno MND, Porro B, Perrucci GL, Valerio V, Alfieri V, Massaiu I, Orekhov AN, Di Minno A, Songia P, Cavalca V, Myasoedova VA, Poggio P. Relationship Between Plasma Osteopontin and Arginine Pathway Metabolites in Patients With Overt Coronary Artery Disease. Front Physiol 2020 Aug 6;11:982. doi: 10.3389/fphys.2020.00982.