Atherosclerotic cardiovascular diseases (ACVDs) continue to be a primary cause of mortality worldwide in adults aged 35-70 years, occurring more often in countries with lower economic development, and is an ever-growing global burden that has a considerable socio-economic impact on society. ACVDs encompass diverse pathologies such as coronary artery disease and heart failure among others. Recent Advances: It is known that oxidative stress plays a relevant role in ACVDs and some of its effects are mediated by lipid oxidation. In particular, lipid peroxidation is a process under which oxidants such as reactive oxygen species attack unsaturated lipids generating a wide array of oxidation products. These molecules can interact with circulating lipoproteins, to diffuse inside the cell and even to cross biological membranes, modifying target nucleophilic sites within biomolecules such as DNA, lipids and proteins, and resulting in a plethora of biological effects.
Gianazza E, Brioschi M, Martinez Fernandez A, Casalnuovo F, Altomare A, Aldini G, Banfi C. LIPID PEROXIDATION IN ATHEROSCLEROTIC CARDIOVASCULAR DISEASES. Antioxid Redox Signal 2020 Jul 8. doi: 10.1089/ars.2019.7955