PCSK6 Is a Key Protease in the Control of Smooth Muscle Cell Function in Vascular Remodeling

Qual è il ruolo della PCSK6 nel rimodellamento vascolare? [Circ Res 2020 Jan 2]

7 Gennaio Gen 2020 22 days ago
  • Veglia F, Baldassarre D, Tremoli E

Proprotein convertase subtilisins/kexins (PCSKs) are a protease family with unknown functions in vasculature. Previously, the Authors of this paper demonstrated PCSK6 upregulation in human atherosclerotic plaques associated with smooth muscle cells (SMCs), inflammation, extracellular matrix (ECM) remodeling and mitogens. Here, they applied a systems biology approach to gain deeper insights into the PCSK6 role in normal and diseased vessel wall.

According to the conclusions, PCSK6 induces SMC migration in response to PDGFB, mechanistically via modulation of contractile markers and MMP14 activation, and is therefore a key regulator of SMC function in vascular remodeling.


Reference
1. Rykaczewska U, Suur BE, Röhl S, Razuvaev A, Lengquist M, Sabater-Lleal M, van der Laan SW, Miller CL, Wirka RC, Kronqvist M, Gonzalez Diez M, Vesterlund M, Gillgren P, Odeberg J, Lindeman JH, Veglia F, Humphries SE, de Faire U, Baldassarre D, Tremoli E, Lehtiö J, Hansson GK, Paulsson-Berne G, Pasterkamp G, Quertermous T, Hamsten A, Eriksson P, Hedin U, Matic L. PCSK6 Is a Key Protease in the Control of Smooth Muscle Cell Function in Vascular Remodeling. Circ Res 2020 Jan 2. doi: 10.1161/CIRCRESAHA.119.316063. Go to PubMed