Pragmatic approach to the use of inotropes for the management of acute and advanced heart failure

Un panel di esperti fa il punto su questa classe di farmaci per la gestione dello scompenso cardiaco (Int J Cardiol 2019 Sep 6. pii: S0167-5273(19)32502-1).

21 Ottobre Ott 2019 5 months ago
  • Agostoni P

Inotropes aim at increasing cardiac output by enhancing cardiac contractility. They constitute the third pharmacological pillar in the treatment of patients with decompensated heart failure, the other two being diuretics and vasodilators.

Three classes of parenterally administered inotropes are currently indicated for decompensated heart failure:

  1. the beta adrenergic agonists, including dopamine and dobutamine and also the catecholamines epinephrine and norepinephrine;
  2. the phosphodiesterase III inhibitor milrinone;
  3. the calcium sensitizer levosimendan.

These three families of drugs share some pharmacologic traits, but differ profoundly in many of their pleiotropic effects. Identifying the patients in need of inotropic support and selecting the proper inotrope in each case remain challenging. The present consensus, derived by a panel meeting of experts from 21 countries, aims at addressing this very issue in the setting of both acute and advanced heart failure.

1. Farmakis D, Agostoni P, Baholli L, Bautin A, Comin-Colet J, Crespo-Leiro MG, Fedele F, García-Pinilla JM, Giannakoulas G, Grigioni F, Gruchała M, Gustafsson F, Harjola VP, Hasin T, Herpain A, Iliodromitis EK, Karason K, Kivikko M, Liaudet L, Ljubas-Maček J, Marini M, Masip J, Mebazaa A, Nikolaou M, Ostadal P, Põder P, Pollesello P, Polyzogopoulou E, Pölzl G, Tschope C, Varpula M, von Lewinski D, Vrtovec B, Yilmaz MB, Zima E, Parissis J. A pragmatic approach to the use of inotropes for the management of acute and advanced heart failure: An expert panel consensus. Int J Cardiol 2019 Sep 6. pii: S0167-5273(19)32502-1. doi: 10.1016/j.ijcard.2019.09.005. Go to PubMed