Perivascular adipose tissue (PVAT) is thought to play a role in vascular homeostasis and in the pathogenesis of large vessel diseases, including abdominal aortic aneurysm (AAA). Herein, the Authors tested the hypothesis that locally restricted transcriptional profiles characterize PVAT surrounding AAA, indicating specific dysfunctions associated with the disease.
To this purpose, the Authors investigated by a genome-wide approach the transcriptome of the adipose stratum surrounding the AAA in comparison with the PVAT of the nondilated proximal neck of the AAA in the same patient. Based on the results obtained, we provide inferences on the functional association between AAA PVAT gene expression signatures and the underlying pathogenic mechanisms.
The results support a possible function of PVAT in AAA pathogenesis and suggest that AAA is an immunologic disease with an underlying autoimmune component. Interfering with these disease-specific pathways would clarify their precise role in AAA pathogenesis.