Rationale and design of the PERFECTION prospective study

Journal of Cardiovascular Computed Tomography

15 Aprile Apr 2016 10 years ago
  • Pontone IMG 7224 A

    Gianluca Pontone

    RESPONSABILE Unità Semplice di Cardiologia dello Sport, Unità Operativa Radiologia, Unità Semplice Cardiologia dello Sport

    DIRETTORE Dipartimento Cardiologia peri-operatoria e Imaging cardiovascolare e ViceDIRETTORE Scientifico

  • Mushtaq Piccola

    Saima Mushtaq

    RESPONSABILE Unità Semplice di TC Cardiovascolare

    EQUIPE MEMBER Unità Semplice di Cardiologia dello Sport, Monzino Women , Unità Semplice Cardiologia dello Sport

    EQUIPE MEMBER Dipartimento di Cardiologia Peri-operatoria e Imaging Cardiovascolare

  • Trabattoni Daniela IMG 6612

    Daniela Trabattoni

    RESPONSABILE Monzino Women , Unità Operativa Cardiologia Interventistica Coronarica e Difetti Cardiaci

    EQUIPE MEMBER Dipartimento di Cardiologia interventistica

  • 043 Cristina Ferrari

    Cristina Ferrari

    EQUIPE MEMBER Monzino Women , Unità Operativa di Cardiologia Interventistica Valvolare e Strutturale

    EQUIPE MEMBER Dipartimento di Cardiologia interventistica

  • Teruzzi

    Giovanni Teruzzi

    EQUIPE MEMBER Unità Operativa Cardiologia Interventistica Coronarica e Difetti Cardiaci

    EQUIPE MEMBER Dipartimento di Cardiologia interventistica

  • Lualdi 2

    Alessandro Lualdi

  • Montorsi IMG 7869

    Piero Montorsi

    RESPONSABILE Unità Operativa Cardiologia Interventistica Coronarica e Periferica

    DIRETTORE Dipartimento di Cardiologia interventistica

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Non-invasive stress tests are commonly used as gatekeepers to invasive coronary angiography (ICA) in patients with suspected coronary artery disease (CAD). New computed tomography angiography (CTA) techniques such as fractional flow reserve calculated by CTA (FFRCT) and stress myocardial computed tomography perfusion (CTP) have emerged as potential strategies to combine anatomical and functional evaluation of CAD in one technique.

The aim of PERFECTION (comparison between stress cardiac computed tomography PERfusion versus Fractional flow rEserve measured by Computed Tomography angiography In the evaluation of suspected cOroNary artery disease) study is to compare per-vessel diagnostic accuracy of FFRCT versus stress myocardial CTP for the detection of functionally significant coronary artery disease (CAD), using invasive FFR as the reference standard.

In the present study, the comparison between FFRCT and stress myocardial CTP will provide understanding about which technology is more accurate for the diagnosis of functionally significant CAD.

Reference: Pontone G, Andreini D, Guaricci AI, Guglielmo M, Mushtaq S, Baggiano A, Beltrama V, Trabattoni D, Ferrari C, Calligaris G, Teruzzi G, Fabbiocchi F, Lualdi A, Montorsi P, Bartorelli AL, Pepi M. Rationale and design of the PERFECTION (comparison between stress cardiac computed tomography PERfusion versus Fractional flow rEserve measured by Computed Tomography angiography In the evaluation of suspected cOroNary artery disease) prospective study. J Cardiovasc Comput Tomogr 2016 [Epub ahead of print]

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