Little is known about the mechanism underlying Sacubitril/Valsartan effects in patients with heart failure (HFrEF). Aim of the study is to assess hemodynamic vs. non-hemodynamic Sacubitril/Valsartan effects by analyzing several biological and functional parameters.
Reference: Impact of Sacubitril/Valsartan on surfactant binding proteins, central sleep apneas, lung function tests and heart failure biomarkers: Hemodynamic or pleiotropism?
Mapelli M, Mattavelli I, Salvioni E, Banfi C, Ghilardi S, De Martino F, Gugliandolo P, Mantegazza V, Volpato V, Basile C, Branco Pires MIF, Sassi V, Nusca B, Vignati C, Contini M, Sforza C, Biondi ML, Perrone Filardi P, Agostoni P. Front Cardiovasc Med. 2022 Sep 15;9:971108.