Left ventricular maximum wall thickness (MWT) is central to diagnosis and risk stratification of hypertrophic cardiomyopathy, but human measurement is prone to variability. We developed an automated machine learning algorithm for MWT measurement and compared precision (reproducibility) with that of 11 international experts, using a dataset of patients with hypertrophic cardiomyopathy.
Augusto JB, Davies RH, Bhuva AN, Knott KD, Seraphim A, Alfarih M, Lau C, Hughes RK, Lopes LR, Shiwani H, Treibel TA, Gerber BL, Hamilton-Craig C, Ntusi NAB, Pontone G, Desai MY, Greenwood JP, Swoboda PP, Captur G, Cavalcante J, Bucciarelli-Ducci C, Petersen SE, Schelbert E, Manisty C, Moon JC. Diagnosis and risk stratification in hypertrophic cardiomyopathy using machine learning wall thickness measurement: a comparison with human test-retest performance. Lancet Digit Health 2021 Jan;3(1):e20-e28.doi: 10.1016/S2589-7500(20)30267-3.