Cellular sex has rarely been considered as a biological variable in preclinical research, even when the pathogenesis of diseases with predictable sex differences is studied. In this perspective, proteomics, and "omics" approaches in general, can provide powerful tools to obtain comprehensive cellular maps, thus favoring the discovery of still unknown sex-biased physio-pathological mechanisms.
Cattaneo MG, Banfi C, Brioschi M, Lattuada D, Vicentini LM. Sex-dependent differences in the secretome of human endothelial cells. Biol Sex Differ 2021 Jan 7;12(1):7.doi: 10.1186/s13293-020-00350-3