Graft patency is one of the major determinants of long-term outcome following coronary artery bypass graft surgery (CABG). Biomarkers, if indicative of the underlying pathophysiological mechanisms, would suggest strategies to limit graft failure. The prognostic value of microvesicles (MVs) for midterm graft patency has never been tested. The aim of this study was to evaluate whether MV pre-operative signature (number, cellular origin, procoagulant phenotype) could predict midterm graft failure and to investigate potential functional role of MVs in graft occlusion.
Camera M, Brambilla M, Canzano P, Cavallotti L, Parolari A, Tedesco CC, Zara C, Rossetti L, Tremoli E. Association of Microvesicles With Graft Patency in Patients Undergoing CABG Surgery. J Am Coll Cardiol 2020 Jun 9;75(22):2819-2832