Pharmacological Inhibition of GRK2 Improves Cardiac Metabolism and Function in Experimental Heart Failure

ESC Heart Failure

4 Maggio Mag 2020 23 days ago
  • Poggio P

The effects of GRK2 inhibition on myocardial metabolism in heart failure (HF) are unchartered. In this work, we evaluated the impact of pharmacological inhibition of GRK2 by a cyclic peptide, C7, on metabolic, biochemical, and functional phenotypes in experimental HF.

Reference

Ciccarelli M, Sorriento D, Fiordelisi A, Gambardella J, Franco A, Del Giudice C, Sala M, Monti MG, Bertamino A, Campiglia P, Oliveti M, Poggio P, Trinchese G, Cavaliere G, Cipolletta E, Mollica MP, Bonaduce D, Trimarco B, Iaccarino G. Pharmacological Inhibition of GRK2 Improves Cardiac Metabolism and Function in Experimental Heart Failure. ESC Heart Fail 2020 Apr 30. doi: 10.1002/ehf2.12706.

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