Melanocortin receptors (MCRs) belong to a hormonal signalling pathway with multiple homeostatic and protective actions. Microvascular and umbilical vein endothelial cells (ECs) express components of the melanocortin system, including the type 1 receptor (MC1R), playing a role in modulating inflammation and vascular tone. Since ECs exhibit a remarkable heterogeneity, we investigated whether human artery ECs express any functional MCR and whether its activation affects cell migration.
Saporiti F, Piacentini L, Alfieri V, Bono E, Ferrari F, Chiesa M, Colombo GI. Melanocortin-1 Receptor Positively Regulates Human Artery Endothelial Cell Migration. Cell Physiol Biochem 2019;52(6):1339-1360. doi: 10.33594/000000094.