ADP-induced platelet activation leads to cell surface expression of several proteins, including TF (tissue factor). The role of ADP receptors in platelet TF modulation is still unknown. We aimed to assess the (1) involvement of P2Y1 and P2Y12 receptors in ADP-induced TF exposure; (2) modulation of TFpos-platelets in anti-P2Y12-treated patients with coronary artery disease. Based on the obtained results, we revisited the intracellular localization of TF in platelets.
Reference: Cell Surface Platelet Tissue Factor Expression: Regulation by P2Y12 and Link to Residual Platelet Reactivity.
Brambilla M, Becchetti A, Rovati G, Cosentino N, Conti M, Canzano P, Giesen PLA, Loffreda A, Bonomi A, Cattaneo M, De Candia E, Podda GM, Trabattoni D, Werba J, Campodonico J, Pinna C, Marenzi G, Tremoli E, Camera M. Arterioscler Thromb Vasc Biol. 2023 Aug 17.