Platelet-derived extracellular vesicles (PEVs) are small vesicles released by activated platelets that are gaining growing interest in the field of vascular biology. The mode of platelet activation is a critical determinant of PEVs release, phenotype and function. However, only very limited information is available concerning the impact of the platelet purification procedure on PEVs release.
Reference: The Impact of Platelet Isolation Protocol on the Release of Extracellular Vesicles. Zarà M, Vismara M, Dona G, Trivigno SMG, Amadio P, Sandrini L, Guidetti GF, Barbieri SS.
Front Biosci (Landmark Ed). 2022 May 18;27(5):161.