Differential diagnosis of wide complex tachycardia in patients taking anti-arrhythmic can be challenging. Conventional ECG diagnostic criteria are poorly specific and should be applied with caution. Patients who develop life-threatening arrhythmias after flecainide infusion should be screened for Brugada Syndrome, especially if concomitant sinus node dysfunction is present.
Wide Complex Tachycardia and Flecainide: A Dangerous Couple. Bergonti M, Ascione C, Tondo C, Sarkozy A. JACC Case Rep. 2021 Sep 1;3(11):1373-1375. doi: 10.1016/j.jaccas.2021.06.019