Alveolar-capillary membrane diffusing capacity for carbon monoxide (DMCO) and pulmonary capillary volume (Vcap) can be estimated by the multi-step Roughton and Foster (RF, original method from 1957) or the single-step NO-CO double diffusion technique (developed in the 1980s). The latter method implies inherent assumptions. We sought to determine which combination of the alveolar membrane diffusing capacity for nitric oxide (DMNO) to DMCO ratio, an specific conductance of the blood for NO (θNO) and CO (θCO) gave the lowest week-to-week variability in patients with heart failure.
Magini A, Zavorsky GS, Apostolo A, Contini M, Barbieri S, Agostoni P. Week to week variability of pulmonary capillary blood volume and alveolar membrane diffusing capacity in patients with heart failure. Respir Physiol Neurobiol 2021 May 4;290:103679. doi: 10.1016/j.resp.2021.103679.