Diabetes mellitus (DM) is a frequent comorbidity in ST-elevation-myocardial infarction (STEMI) patients and carries a higher risk of in-hospital mortality. We recently demonstrated that the higher in-hospital mortality of STEMI patients with DM, when compared to that of patients without DM, is mainly associated with their more frequent cardiac and renal dysfunction. These exploratory results prompted us to hypothesize that this higher risk in DM patients is mediated by their lower cardio-renal functional reserve.
Cosentino N, Bonomi A, Campodonico J, Veglia F, De Ferrari GM, Genovese S, Marenzi G. Can the in-hospital mortality gap between STEMI patients with and without diabetes mellitus be reduced? The cardio-renal hypothesis. Nutr Metab Cardiovasc Dis 2021 Feb 13;S0939-4753(21)00052-1.doi: 10.1016/j.numecd.2021.02.003