This was a retrospective analysis of a prospective international registry of consecutive patients with laboratory-confirmed COVID-19 and chest CT imaging, admitted to four centers between January 10 and May 6, 2020. Total burden (expressed as a percentage) and mean attenuation of ground glass opacities (GGO) and consolidation were quantified from CT using semi-automated research software. The primary outcome was clinical deterioration (intensive care unit admission, invasive mechanical ventilation, or vasopressor therapy) or in-hospital death. Logistic regression was performed to assess the predictive value of clinical and CT parameters for the primary outcome.
Grodecki K, Lin A, Cadet S, McElhinney PA, Razipour A, Chan C, Pressman B, Julien P, Maurovich-Horvat P, Gaibazzi N, Thakur U, Mancini E, Agalbato C, Menè R, Parati G, Cernigliaro F, Nerlekar N, Torlasco C, Pontone G, Slomka PJ, Dey D. Quantitative Burden of COVID-19 Pneumonia on Chest CT Predicts Adverse Outcomes: A Post-Hoc Analysis of a Prospective International Registry. Radiol Cardiothorac Imaging 2020 Oct 1;2(5):e200389.doi: 10.1148/ryct.2020200389.