Mitral valve prolapse (MVP) associated with severe mitral regurgitation is a debilitating disease with no pharmacological therapies available. MicroRNAs (miRNA) represent an emerging class of circulating biomarkers that have never been evaluated in MVP human plasma. Our aim was to identify a possible miRNA signature that is able to discriminate MVP patients from healthy subjects (CTRL) and to shed light on the putative altered molecular pathways in MVP.
Songia P, Chiesa M, Alfieri V, Massaiu I, Moschetta D, Myasoedova V, Valerio V, Fusini L, Gripari P, Zanobini M, Poggio P. Putative Circulating MicroRNAs Are Able to Identify Patients with Mitral Valve Prolapse and Severe Regurgitation. Int J Mol Sci 2021 Feb 20;22(4):2102. doi: 10.3390/ijms22042102