Takotsubo (TTS) syndrome is an acute cardiac condition characterized by transient and reversible left ventricle dysfunction that mainly affects postmenopausal women. Catecholamine burst is the most accredited mechanism underpinning TTS onset and leading to endothelial dysfunction and platelet activation. Even if the use of low dose acetylsalycilic acid (ASA) in this clinical setting is based on both clinical presentation and unfavorable long-term prognosis, its efficacy has been recently challenged.
Amadio P, Porro B, Cavalca V, Barbieri SS, Eligini S, Fiorelli S, Di Minno A, Gorini A, Giuliani M, Werba JP, Cosentino N, Olivares P, Barbieri S, Veglia F, Tremoli E, Trabattoni D. Persistent long-term platelet activation and endothelial perturbation in women with Takotsubo syndrome. Biomed Pharmacother 2021 Jan 12;136:111259. doi: 10.1016/j.biopha.2021.111259.