Lipoprotein Lipase (LPL) is known to be a key enzyme for lipid metabolism specifically in an enzymatic glycoprotein which provide tissues without fatty-acids and eliminates triglycerides (TG) by the circulation. Mutations in LPL were proven to cause alteration in fractions within lipoprotein, causing the development of atherosclerosis which predispose to weakening coronary artery disease (CAD) and stroke. We examined the linkage between genetic variant HindIII in LPL on lipoprotein fractions, stroke occurrences and CAD.
Bogari NM, Aljohani A, Dannoun A, Elkhateeb O, Porqueddu M, Amin AA, Bogari DN, Taher MM, Buba F, Allam RM, Bogari MN, Alamanni F. Association between HindIII (rs320) variant in the lipoprotein lipase gene and the presence of coronary artery disease and stroke among the Saudi population. Saudi J Biol Sci 2020 Aug;27(8):2018-2024. doi: 10.1016/j.sjbs.2020.06.029