Pharmacological Inhibition of GRK2 Improves Cardiac Metabolism and Function in Experimental Heart Failure
ESC Heart Failure
4
May
May
2020
5 years ago
The effects of GRK2 inhibition on myocardial metabolism in heart failure (HF) are unchartered. In this work, we evaluated the impact of pharmacological inhibition of GRK2 by a cyclic peptide, C7, on metabolic, biochemical, and functional phenotypes in experimental HF.
Reference
Ciccarelli M, Sorriento D, Fiordelisi A, Gambardella J, Franco A, Del Giudice C, Sala M, Monti MG, Bertamino A, Campiglia P, Oliveti M, Poggio P, Trinchese G, Cavaliere G, Cipolletta E, Mollica MP, Bonaduce D, Trimarco B, Iaccarino G. Pharmacological Inhibition of GRK2 Improves Cardiac Metabolism and Function in Experimental Heart Failure. ESC Heart Fail 2020 Apr 30. doi: 10.1002/ehf2.12706.