Differences in Progression to Obstructive Lesions per High-Risk Plaque Features and Plaque Volumes With CCTA

It is still debatable whether HRP simply represents a certain phase during the natural history of coronary atherosclerotic plaques or if disease progression would differ according to the presence of HRP. This study explored whether the pattern of nonobstructive lesion progression into obstructive lesions would differ according to the presence of high-risk plaque (HRP).

The results confirm that the pattern of progression differed according to the presence of HRP; and baseline percent atheroma volume, not the presence of HRP features, was the most important predictor of lesions developing into obstructive lesions.

Reference

1. Lee SE, Sung JM, Andreini D, Al-Mallah MH, Budoff MJ, Cademartiri F, Chinnaiyan K, Choi JH, Chun EJ, Conte E, Gottlieb I, Hadamitzky M, Kim YJ, Lee BK, Leipsic JA, Maffei E, Marques H, de Araújo Gonçalves P, Pontone G, Raff GL, Shin S, Stone PH, Samady H, Virmani R, Narula J, Berman DS, Shaw LJ, Bax JJ, Lin FY, Min JK, Chang HJ. Differences in Progression to Obstructive Lesions per High-Risk Plaque Features and Plaque Volumes With CCTA. JACC Cardiovasc Imaging 2019 Nov 6. pii: S1936-878X(19)30934-9. doi: 10.1016/j.jcmg.2019.09.011. Go to PubMed