Impact of Insulin-Treated and Noninsulin-Treated Diabetes Mellitus in Patients Undergoing PCI

Patients with diabetes mellitus (DM) have worse outcomes after percutaneous coronary intervention (PCI). Recent evidences suggest a differential impact of insulin-treated and non insulin-treated DM on prognosis. The Authors of this study evaluated the clinical outcome of diabetic patients after PCI with polymer-free biolimus-eluting stent from the RUDI-FREE Registry, investigating a possible different prognostic impact of insulin-treated and non insulin-treated DM.

According to the conclusions, patients with DM had a higher risk of target lesion failure (TLF; composite of cardiac death, target vessel myocardial infarction, target lesion revascularization) compared with non diabetics. Nonetheless, the worse outcome of the diabetic population seems to be driven by the insulin-treated diabetic subpopulation.

This finding suggests a different risk profile of insulin-treated and non insulin-treated diabetic patients in the modern era of PCI.

Reference

1. Pepe M, Sardella G, Stefanini GG, Corcione N, Nestola PL, Morello A, Briguori C, Tamburino C, Fabbiocchi F, Rotolo FL, Tomai F, Paggi A, Lombardi M, Gioffrè G, Sclafani R, Rolandi A, Sciahbasi A, Scardaci F, Signore N, Mancone M, Giordano A. Impact of Insulin-Treated and Noninsulin-Treated Diabetes Mellitus in All-Comer Patients Undergoing Percutaneous Coronary Interventions With Polymer-Free Biolimus-Eluting Stent (from the RUDI-FREE Registry). Am J Cardiol2019 Aug 23. pii: S0002-9149(19)30956-7. doi: 10.1016/j.amjcard.2019.08.015. Go to PubMed