Aortic valve sclerosis (AVSc), a non-uniform thickening of leaflets with an unrestricted opening, is characterized by inflammation, lipoprotein deposition, and matrix degradation. In the general population, AVSc predicts long-term cardiovascular mortality (+50%) even after adjustment for vascular risk factors and clinical atherosclerosis. We have hypothesized that AVSc is a risk-multiplier able to predict even short-term mortality. To address this issue, we retrospectively analyzed 90-day mortality of all patients who underwent isolated coronary artery bypass grafting (CABG) at Centro Cardiologico Monzino over a ten-year period (2006-2016).
Poggio P, Cavallotti L, Myasoedova VA, Bonomi A, Songia P, Gripari P, Valerio V, Amato M, Barbieri S, Faggiano P, Alamanni F, Veglia F, Pepi M, Tremoli E, Baldassarre D. Aortic Valve Sclerosis Adds to Prediction of Short-Term Mortality in Patients with Documented Coronary Atherosclerosis. J Clin Med 2019 Aug 5;8(8). pii: E1172. doi: 10.3390/jcm8081172.