In pregnancy complicated by gestational diabetes mellitus (GDM), the human placenta shows several pathological functional and structural changes, but the extent to which maternal glycemic control contributes to placental abnormalities remains unclear. The aim of this study was to profile and compare the proteome of placentas from healthy pregnant women and those with GDM, to investigate the placenta-specific protein composition and possible changes of its function in presence of GDM.
Burlina S, Banfi C, Brioschi M, Visentin S, Dalfrà MG, Traldi P, Lapolla A. Is the placental proteome impaired in well-controlled gestational diabetes? J Mass Spectrom 2019 Apr;54(4):359-365