A proteomic approach to identify novel disease biomarkers in LCAT deficiency

This investigation defines the effects of LCAT deficiency on the level of the major plasma proteins in homozygous and heterozygous carriers. Increase for some proteins, with different function, together with a drop for haptoglobin, and specifically for haptoglobin beta chains, are reported for the first time as part of a coherent signature.

Reference

Simonelli S, Ossoli A, Banfi C, Pavanello C, Calabresi L, Gianazza E. A proteomic approach to identify novel disease biomarkers in LCAT deficiency. J Proteomics 2018 Dec 6. pii: S1874-3919(18)30427-5. doi: 10.1016/j.jprot.2018.12.005. [Epub ahead of print]

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