Evaluation of coronary arteries and myocardial perfusion with single stress CCT acquisition

Coronary computed tomography angiography (cCTA) has limited diagnostic accuracy in patients with intermediate to high pre-test likelihood of coronary artery disease (CAD) that may have large amounts of coronary calcium.

Stress computed tomography myocardial perfusion (CTP) has emerged as a valuable strategy, combining anatomical and functional assessment of CAD.

Purpose of the study is to evaluate the diagnostic accuracy of combining coronary artery imaging and myocardial perfusion in a single stress dataset (130 consecutive symptomatic patients, age: 65 ± 9 years; men: 70%, scheduled for clinically indicated ICA plus invasive FFR) versus invasive coronary angiography (ICA) and invasive fractional flow reserve (FFR) as reference standard.

According to the conclusions of the paper, simultaneous evaluation of coronary arteries and myocardial perfusion with single stress acquisition is feasible and it has diagnostic accuracy and low effective dose to identify functionally significant stenosis in patients with intermediate to high risk for CAD.

Reference

1. Pontone G, Baggiano A, Andreini D, Guaricci AI, Guglielmo M, Muscogiuri G, Fusini L, Soldi M, Del Torto A, Mushtaq S, Conte E, Calligaris G, De Martini S, Ferrari C, Galli S, Grancini L, Olivares P, Ravagnani P, Teruzzi G, Trabattoni D, Fabbiocchi F, Montorsi P, Rabbat MG, Bartorelli AL, Pepi M. Diagnostic accuracy of simultaneous evaluation of coronary arteries and myocardial perfusion with single stress cardiac computed tomography acquisition compared to invasive coronary angiography plus invasive fractional flow reserve. Int J Cardiol 2018 Sep 20. pii: S0167-5273(18)33743-4. doi: 10.1016/j.ijcard.2018.09.065. [Epub ahead of print] Go to PubMed