Clinical and prognostic impact of chronotropic incompetence in patients with hypertrophic cardiomyopathy

A blunted heart rate (HR) response is associated with an impaired peak oxygen uptake (pVO₂), a powerful outcome predictor in hypertrophic cardiomyopathy (HCM). The present multicenter study with 681 consecutive HCM outpatients on optimized treatment ,sought to determine the prognostic role for exercise-induced HR response in HCM.

The cardiopulmonary exercise test is pivotal in the HCM management, however the pHR remains a meaningful alternative parameter. A pHR < 70% identified a HCM population at high risk of HF-related events, thus calling for a reappraisal of the chronotropic incompetence threshold in HCM.

Reference

1. Magri D, Agostoni P, Sinagra G, Re F, Correale M, Limongelli G, Zachara E, Mastromarino V, Santolamazza C, Casenghi M, Pacileo G, Valente F, Morosin M, Musumeci B, Pagannone E, Maruotti A, Uguccioni M, Volpe M, Autore C. Clinical and prognostic impact of chronotropic incompetence in patients with hypertrophic cardiomyopathy. Int J Cardiol 2018 Aug 4. pii: S0167-5273(17)36583-X. doi: 10.1016/j.ijcard.2018.04.019. [Epub ahead of print] Go to PubMed