Relationship between Serum Inflammatory Biomarkers and Thrombus Characteristics in Patients with ST Segment Elevation Myocardial Infarction

Aim of this paper was to compare angiographic and optical coherence tomography (OCT) data pertinent to thrombi, along with the histologic characteristics of aspirated thrombi in patients presenting with ST elevation myocardial infarction (STEMI) with or without inflammation, as assessed by C-reactive protein (CRP) and myeloperoxidase (MPO).

Studying 140 patients with STEMI referred for primary percutaneous intervention, from the OCTAVIA (Optical Coherence Tomography Assessment of Gender Diversity in Primary Angioplasty) study, CRP and MPO was not correlated in STEMI patients, possibly reflecting different pathogenic mechanisms, with CRP more related to thrombus burden and MPO to thrombus age.

Reference

• Niccoli G, Menozzi A, Capodanno D, Trani C, Sirbu V, Fineschi M, Zara C, Crea F, Trabattoni D, Saia F, Ladich E, Biondi Zoccai G, Attizzani G, Guagliumi G. Relationship between Serum Inflammatory Biomarkers and Thrombus Characteristics in Patients with ST Segment Elevation Myocardial Infarction. Cardiology 2016;137(1):27-35 Go to PubMed