Role of thromboxane-dependent platelet activation in venous thrombosis: Aspirin effects in mouse model

Pharmacological Research

26 April Apr 2016 9 years ago
  • Eva Tarantino, Patrizia Amadio, Isabella Squellerio, Benedetta Porro, Leonardo Sandrini, Linda Turnu , Viviana Cavalca, Elena Tremoli, Silvia S Barbieri
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Recent trials suggest that Aspirin (ASA) reduces the incidence of venous thromboembolism in human. However, the molecular mechanisms underlying this effect are still unclear. In this study we assessed the effects of ASA in venous thrombosis mouse model induced by inferior vena cava (IVC) ligation and we investigated the mechanisms responsible for this effect.

Reference
Tarantino E, Amadio P, Squellerio I, Porro B, Sandrini L, Turnu L, Cavalca V, Tremoli E, Barbieri SS. Role of thromboxane-dependent platelet activation in venous thrombosis: Aspirin effects in mouse model. Pharmacol Res 2016;107:415-425

Go to PubMed http://www.ncbi.nlm.nih.gov/pubmed/27063941