On-chip assessment of human primary cardiac fibroblasts proliferative responses to uniaxial cyclic mechanical strain

Biotechnol Bioeng

26 October Oct 2015 10 years ago
  • Ugolini GS, Rasponi M, Pavesi A, Santoro R, Kamm R, Fiore GB, Pesce M, Soncini M
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In this work we have designed, developed and employed a microdevice for application of uniform and uniaxial cyclic strain to cell monolayers. We designed this device specifically to minimize the number of cells required and to increase throughput and ease of use. We characterized the strain applied and then employed the microdevice to investigate biological responses of human heart-derived adult CFs to cyclic strain.
 
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