Abnormalmegakaryopoiesis and platelet function in cyclooxygenase-2-deficient mice

Thromb Haemost

7 September Sep 2015 10 years ago
  • Barbieri SS, Petrucci G, Tarantino E, Amadio P, Rocca B, Pesce M, Machlus K, Ranelletti FO, Gianellini S, Weksler B, Italiano JE Jr, Tremoli E
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Previous studies suggest that cyclooxygenase-2 (COX-2) might influence megakaryocyte maturation and platelet production in vitro. Using a gene deletion model, we analysed the effect of COX-2 deficiency on megakaryopoiesis and platelet function.