Natural anticoagulants deficiency and the risk of venous thromboembolism: a meta-analysis of observational studies

Natural anticoagulants deficiency (antithrombin , protein C, protein S) is a rare, but potent risk factor for venous thromboembolism. We performed a meta-analysis of observational studies evaluating the impact of inherited natural anticoagulants deficiency on venous thromboembolism risk.

The study found that The VTE risk is increased in patients with natural anticoagulants deficiency, but additional studies are warranted to better assess the risk of VTE recurrence.

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