Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity?
Obes Rev. 2015 Apr;16(4):327-340
23
March
Mar
2015
11 years ago
Previously, a single nucleotide polymorphism (SNP), rs9939609, in the FTO gene showed a much stronger association with all-cause mortality than expected from its association with body mass index (BMI), body fat mass index (FMI) and waist circumference (WC).
This finding implies that the SNP has strong pleiotropic effects on adiposity and adiposity-independent pathological pathways that leads to increased mortality. To investigate this further, was conducted a meta-analysis of similar data from 34 longitudinal studies including 169,551 adult Caucasians among whom 27,100 died during follow-up. The results do not support that the FTO SNP is associated with all-cause mortality independently of the adiposity phenotypes.
Go to NCBI abstract
This finding implies that the SNP has strong pleiotropic effects on adiposity and adiposity-independent pathological pathways that leads to increased mortality. To investigate this further, was conducted a meta-analysis of similar data from 34 longitudinal studies including 169,551 adult Caucasians among whom 27,100 died during follow-up. The results do not support that the FTO SNP is associated with all-cause mortality independently of the adiposity phenotypes.
Go to NCBI abstract