Proteomics of tissue factor silencing in cardiomyocytic cells reveals a new role for this coagulation factor in splicing machinery control

It has long been known that Tissue Factor (TF) plays a role in blood coagulation and has a direct thrombotic action that is closely related to cardiovascular risk, but it is becoming increasingly clear that it has a much wider range of biological functions that range from inflammation to immunity.

In this study, using quantitative proteomics and functional biochemical approaches, the Authors define for the first time that Tissue Factor plays a novel role in regulating cell splicing machinery, in addition to its primary role in blood coagulation, with a relevant impact on cell survival.

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