Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index

PLoS Genet

15 October Oct 2014 11 years ago
  • Hoggart CJ, Venturini G, Mangino M, Gomez F, Ascari G, Zhao JH, Teumer A, Winkler TW, Tšernikova N, Luan J, Mihailov E, et al. Tremoli E tra i collaboratori
In this paper a novel approach to detect parent-of-origin effects (POEs) in genome-wide genotype data of unrelated individuals is presented. The method exploits increased phenotypic variance in the heterozygous genotype group relative to the homozygous groups.