Plaque morphologic measures on coronary computed tomography angiography (CCTA) have been associated with future acute coronary syndrome (ACS). However, the evolution of calcified coronary plaques by noninvasive imaging is not known. Objective of this study was to ascertain whether the increasing density in calcified coronary plaque is associated with risk for ACS.
A new multicenter case-control cohort study tried to ascertain whether the increasing density in calcified coronary plaque is associated with risk for ACS, on a total of 189 patients and 189 matched controls.
Results of this study suggest that, on a per-patient and per-lesion basis, 1K plaque was associated with a lower risk for future ACS and that measurement of 1K plaque may improve risk stratification beyond plaque burden.
1. van Rosendael AR, Narula J, Lin FY, van den Hoogen IJ, Gianni U, Al Hussein Alawamlh O, Dunham PC, Peña JM, Lee SE, Andreini D, Cademartiri F, Chinnaiyan K, Chow BJW, Conte E, Cury RC, Feuchtner G, Hadamitzky M, Kim YJ, Leipsic J, Maffei E, Marques H, de Araújo Gonçalves P, Plank F, Pontone G, Raff GL, Villines TC, Weirich HG, Al'Aref SJ, Baskaran L, Cho I, Danad I, Han D, Heo R, Lee JH, Rivzi A, Stuijfzand WJ, Gransar H, Lu Y, Sung JM, Park HB, Samady H, Stone PH, Virmani R, Budoff MJ, Berman DS, Chang HJ, Bax JJ, Min JK, Shaw LJ. Association of High-Density Calcified 1K Plaque With Risk of Acute Coronary Syndrome. JAMA Cardiol 2020 Jan 22. doi: 10.1001/jamacardio.2019.5315. Go to PubMed