Noncontrast Magnetic Resonance for the Diagnosis of Cardiac Amyloidosis

Cardiac Amyloidosis (CA) is a progressive and fatal underdiagnosed cause of heart failure. Cardiovascular magnetic resonance (CMR) has emerged as an extremely useful test for the non-invasive diagnosis of CA, but administration of contrast is still required to make a diagnosis.

This study aimed to assess the diagnostic use of native T1 to detect cardiac amyloidosis in a large prospective cohort of patients referred for suspected systemic amyloidosis.

According to the conclusions, native myocardial T1 enables diagnosis of CA to be made without need for gadolinium contrast in a large proportion of patients with suspected systemic amyloidosis. The Authors also propose a diagnostic algorithm for non-contrast CMR applicable to patients with suspected amyloidosis.

Reference

1. Baggiano A, Boldrini M, Martinez-Naharro A, Kotecha T, Petrie A, Rezk T, Gritti M, Quarta C, Knight DS, Wechalekar AD, Lachmann HJ, Perlini S, Pontone G, Moon JC, Kellman P, Gillmore JD, Hawkins PN, Fontana M. Noncontrast Magnetic Resonance for the Diagnosis of Cardiac Amyloidosis. JACC Cardiovasc Imaging 2019 Jun 7. pii: S1936-878X(19)30433-4. doi: 10.1016/j.jcmg.2019.03.026. Go to PubMed