Cardiac Amyloidosis (CA) is a progressive and fatal underdiagnosed cause of heart failure. Cardiovascular magnetic resonance (CMR) has emerged as an extremely useful test for the non-invasive diagnosis of CA, but administration of contrast is still required to make a diagnosis.
This study aimed to assess the diagnostic use of native T1 to detect cardiac amyloidosis in a large prospective cohort of patients referred for suspected systemic amyloidosis.
According to the conclusions, native myocardial T1 enables diagnosis of CA to be made without need for gadolinium contrast in a large proportion of patients with suspected systemic amyloidosis. The Authors also propose a diagnostic algorithm for non-contrast CMR applicable to patients with suspected amyloidosis.