PCSK9 Involvement in Aortic Valve Calcification

Journal of the American College of Cardiology

27 December Dec 2018 22 days ago
  • Poggio P, Songia P, Cavallotti L, Barbieri SS, Camera M

(Letter to the Editor) High levels of proprotein convertase subtilisin/kexin 9 (PCSK9) (>305 ng/ml) have been recently associated, along with insulin resistance and lipoproteinassociated phospholipase A2 activity, with aortic bioprosthesis calcification and able to predict hemodynamic valve deterioration. Interestingly, high levels of PCSK9 have been previously shown also to correlate with the presence of calcific aortic valve stenosis (CAVS), and an early study showed that carriers of the PCSK9 R46L loss-of-function genetic variant might have a low CAVS risk.

In the present analysis, the Authors took advantage of the PCSK9 knockout mouse model to explore the link between PCSK9 and aortic valve calcification (AVC). In addition, in human specimens, they evaluated if there was an association between AVC and PCSK9 valve content.


Reference
1. Poggio P, Songia P, Cavallotti L, Barbieri SS, Zanotti I, Arsenault BJ, Valerio V, Ferri N, Capoulade R, Camera M. PCSK9 Involvement in Aortic Valve Calcification. J Am Coll Cardiol 2018 Dec 18;72(24):3225-3227 Go to PubMed