PCSK9 promotes arterial medial calcification

A complex interplay among chronic kidney disease (CKD), lipid metabolism and aortic calcification has been recognized. Here we investigated the influence of kidney function on PCSK9 levels and its potential direct action on smooth muscle cells (SMCs) calcification.

Reference: PCSK9 promotes arterial medial calcification. Lupo MG, Bressan A, Donato M, Canzano P, Camera M, Poggio P, Greco MF, Garofalo M, De Martin S, Panighel G, Ruscica M, Baragetti A, Bollati V, Faggin E, Rattazzi M, Catapano AL, Ferri N. Atherosclerosis. 2022 Jan 22:S0021-9150(22)00029-6.

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