Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration

Come interpretare le variazioni nell'IMT nei pazienti ad alto rischio cardiovascolare? (PLoS One 2018 Apr 12)

23 Aprile Apr 2018 one month ago
  • Baldassarre D, Veglia f, Tremoli E

Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. The Authors of this study assessed the relation between CIMT change and events in individuals at high cardiovascular risk and confirm that common CIMT is associated with future CVD events in individuals at high risk.

However, although common CIMT is associated with future CVD event risk, this is not apparently true for common CIMT change over time. Reasons may include the complexity of atherosclerotic process, and technical limits of current CIMT measurement.

Do these null findings mean that CIMT (change) is not scientifically useful? The results of this study confirm that CIMT is still a very useful biomarker, with close associations with both risk factors and future endpoints. The change of CIMT, however, should be interpreted with care.

Reference
1. Lorenz MW, Gao L, Ziegelbauer K, Norata GD, Empana JP, Schmidtmann I, Lin HJ, McLachlan S, Bokemark L, Ronkainen K, Amato M, Schminke U, Srinivasan SR, Lind L, Okazaki S, Stehouwer CDA, Willeit P, Polak JF, Steinmetz H, Sander D, Poppert H, Desvarieux M, Ikram MA, Johnsen SH, Staub D, Sirtori CR, Iglseder B, Beloqui O, Engström G, Friera A, Rozza F, Xie W, Parraga G, Grigore L, Plichart M, Blankenberg S, Su TC, Schmidt C, Tuomainen TP, Veglia F, Völzke H, Nijpels G, Willeit J, Sacco RL, Franco OH, Uthoff H, Hedblad B, Suarez C, Izzo R, Zhao D, Wannarong T, Catapano A, Ducimetiere P, Espinola-Klein C, Chien KL, Price JF, Bergström G, Kauhanen J, Tremoli E, Dörr M, Berenson G, Kitagawa K, Dekker JM, Kiechl S, Sitzer M, Bickel H, Rundek T, Hofman A, Mathiesen EB, Castelnuovo S, Landecho MF, Rosvall M, Gabriel R, de Luca N, Liu J, Baldassarre D, Kavousi M, de Groot E, Bots ML, Yanez DN, Thompson SG; PROG-IMT study group. Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration. PLoS One 2018 Apr 12;13(4):e0191172. Go to PubMed